1. Biology Dictionary
  2. Immune checkpoint inhibitors (ICIs)

Immune checkpoint inhibitors (ICIs)

Definition:

Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that antagonize immune inhibitory pathways known as checkpoints. The most widely used ICIs are anti CTLA-4, anti Programmed death receptor 1 (PD-1), and anti Programmed cell death ligand 1 (PD-L1) antibodies. These drugs are not thought to be directly tumoricidal,but rather indirectly mediate anti-tumor effects by inducing T cell activation mechanisms.

Biomedical Dictionary

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