2. Biology Dictionary
  3. Interleukin 1 receptor antagonist deficiency (DIRA)

Interleukin 1 receptor antagonist deficiency (DIRA)

Definition:

Interleukin 1 receptor antagonist deficiency (DIRA) is a rare autosomal recessive autoinflammatory disease caused by mutations in IL1RN. The absence of interleukin 1 receptor (IL-1R) antagonist allows unopposed action of IL-1, resulting in life threatening systemic inflammation with skin and bone involvement.

Biomedical Dictionary

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