Intracellular hyaluronan-binding protein 4

Definition:

RNA-binding protein that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation. Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity). Plays a role in pre-mRNA splicing regulation. Binds (via C-terminus) to poly(U) RNA. Involved in mRNA translation regulation, probably at the initiation step. Seems to play a role in PML-nuclear bodies formation.

References:

[1]. Gustavo C Bressan, et al. Functional association of human Ki-1/57 with pre-mRNA splicing events. FEBS J. 2009 Jul;276(14):3770-83. [Content Brief]

[2]. Ângela Saito, et al. Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and Affects PML Nuclear Body Formation. J Proteome Res. 2017 Sep 1;16(9):3147-3157. [Content Brief]

[3]. Flávia C Nery, et al. Evidence for the interaction of the regulatory protein Ki-1/57 with p53 and its interacting proteins. Biochem Biophys Res Commun. 2006 Mar 17;341(3):847-55. [Content Brief]

[4]. Kaliandra de Almeida Gonçalves, et al. Evidence for the association of the human regulatory protein Ki-1/57 with the translational machinery. FEBS Lett. 2011 Aug 19;585(16):2556-60. [Content Brief]

[5]. Flávia C Nery, et al. Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C. J Biol Chem. 2004 Mar 19;279(12):11444-55. [Content Brief]

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