Isocitrate dehydrogenase [NADP], mitochondrial

Definition:

Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.

References:

[1]. Hai Yan, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009 Feb 19;360(8):765-73. [Content Brief]

[2]. Wei Yu, et al. SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status. J Biol Chem. 2012 Apr 20;287(17):14078-86. [Content Brief]

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