Janus kinase 1 (JAK1)

Definition:

Janus kinase-1 (JAK1) tyrosine kinase mediates signaling from multiple cytokine receptors, including interferon alpha/beta and gamma (IFN-α/β and IFN-γ), which are important for viral and mycobacterial protection respectively.

References:

[1]. Daza-Cajigal V, et al. Partial human Janus kinase 1 deficiency predominantly impairs responses to interferon gamma and intracellular control of mycobacteria. Front Immunol. 2022 Sep 9;13:888427. [Content Brief]

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