Killer cell immunoglobulin-like receptor 3DS1

Definition:

Receptor on natural killer (NK) cells for MHC class I molecules. Upon interaction with peptide-free HLA-F open conformer, triggers NK cell degranulation and anti-viral cytokine production.

References:

[1]. Wilfredo F Garcia-Beltran, et al. Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1. Nat Immunol. 2016 Sep;17(9):1067-74. [Content Brief]

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