Melanoma inhibitory activity protein 2

Definition:

Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum. Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites.

References:

[1]. Tomoya Tanabe, et al. Dual function of cTAGE5 in collagen export from the endoplasmic reticulum. Mol Biol Cell. 2016 Jul 1;27(13):2008-13. [Content Brief]

[2]. Kota Saito, et al. Concentration of Sec12 at ER exit sites via interaction with cTAGE5 is required for collagen export. J Cell Biol. 2014 Sep 15;206(6):751-62. [Content Brief]

[3]. Kota Saito, et al. cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites. Mol Biol Cell. 2011 Jul 1;22(13):2301-8. [Content Brief]

[4]. António J M Santos, et al. TANGO1 and Mia2/cTAGE5 (TALI) cooperate to export bulky pre-chylomicrons/VLDLs from the endoplasmic reticulum. J Cell Biol. 2016 May 9;213(3):343-54. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.