Melanoma inhibitory activity protein 2

Definition

Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum. Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites.

References:

[1]. Tomoya Tanabe, et al. Dual function of cTAGE5 in collagen export from the endoplasmic reticulum. Mol Biol Cell. 2016 Jul 1;27(13):2008-13. [Content Brief]

[2]. Kota Saito, et al. Concentration of Sec12 at ER exit sites via interaction with cTAGE5 is required for collagen export. J Cell Biol. 2014 Sep 15;206(6):751-62. [Content Brief]

[3]. Kota Saito, et al. cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites. Mol Biol Cell. 2011 Jul 1;22(13):2301-8. [Content Brief]

[4]. António J M Santos, et al. TANGO1 and Mia2/cTAGE5 (TALI) cooperate to export bulky pre-chylomicrons/VLDLs from the endoplasmic reticulum. J Cell Biol. 2016 May 9;213(3):343-54. [Content Brief]

生物医学辞典

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