Methionine--tRNA ligase, cytoplasmic

Definition:

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus.

References:

[1]. M Kaminska, et al. The appended C-domain of human methionyl-tRNA synthetase has a tRNA-sequestering function. Biochemistry. 2001 Nov 27;40(47):14309-16. [Content Brief]

[2]. Y G Ko, et al. Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis. J Cell Biol. 2000 May 1;149(3):567-74. [Content Brief]

[3]. Elena Botta, et al. Protein instability associated with AARS1 and MARS1 mutations causes trichothiodystrophy. Hum Mol Genet. 2021 Aug 28;30(18):1711-1720. [Content Brief]

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