Microtubule-associated proteins 1A/1B light chain 3A

Definition:

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover.

References:

[1]. Haruka Chino, et al. Intrinsically Disordered Protein TEX264 Mediates ER-phagy. Mol Cell. 2019 Jun 6;74(5):909-921.e6. [Content Brief]

[2]. Salvatore J Cherra 3rd, et al. Regulation of the autophagy protein LC3 by phosphorylation. J Cell Biol. 2010 Aug 23;190(4):533-9. [Content Brief]

[3]. Hironori Suzuki, et al. Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism. Structure. 2014 Jan 7;22(1):47-58. [Content Brief]

[4]. Heeseon An, et al. TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress. Mol Cell. 2019 Jun 6;74(5):891-908.e10. [Content Brief]

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