Microtubule-associated tumor suppressor 1

Definition:

Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.

References:

[1]. Stefan Seibold, et al. Identification of a new tumor suppressor gene located at chromosome 8p21.3-22. FASEB J. 2003 Jun;17(9):1180-2. [Content Brief]

[2]. Sylvie Rodrigues-Ferreira, et al. 8p22 MTUS1 gene product ATIP3 is a novel anti-mitotic protein underexpressed in invasive breast carcinoma of poor prognosis. PLoS One. 2009 Oct 1;4(10):e7239. [Content Brief]

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