Mitochondrial import inner membrane translocase subunit Tim29

Definition:

Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. Required for the stability of the TIM22 complex and functions in the assembly of the TIMM22 protein into the TIM22 complex. May facilitate cooperation between TIM22 and TOM complexes by interacting with TOMM40.

References:

[1]. Sylvie Callegari, et al. TIM29 is a subunit of the human carrier translocase required for protein transport. FEBS Lett. 2016 Dec;590(23):4147-4158. [Content Brief]

[2]. Yilin Kang, et al. Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability. Elife. 2016 Aug 24;5:e17463. [Content Brief]

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