Mitogen-activated protein kinase kinase kinase 2

Definition:

Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.

References:

[1]. Lucas Pelkmans, et al. Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae. Nature. 2005 Jul 7;436(7047):128-33. [Content Brief]

[2]. J Cheng, et al. Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. Mol Cell Biol. 2000 Apr;20(7):2334-42. [Content Brief]

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