Monocarboxylate transporter 12

Definition:

Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH. Contributes to the process of creatine biosynthesis and distribution.

References:

[1]. Jeannette Abplanalp, et al. The cataract and glucosuria associated monocarboxylate transporter MCT12 is a new creatine transporter. Hum Mol Genet. 2013 Aug 15;22(16):3218-26. [Content Brief]

[2]. Nasser Dhayat, et al. Mutation in the Monocarboxylate Transporter 12 Gene Affects Guanidinoacetate Excretion but Does Not Cause Glucosuria. J Am Soc Nephrol. 2016 May;27(5):1426-36. [Content Brief]

[3]. Masaki Takahashi, et al. Functional characterization of monocarboxylate transporter 12 (SLC16A12/MCT12) as a facilitative creatine transporter. Drug Metab Pharmacokinet. 2020 Jun;35(3):281-287. [Content Brief]

[4]. Ryuta Jomura, et al. Monocarboxylate transporter 12 as a guanidinoacetate efflux transporter in renal proximal tubular epithelial cells. Biochim Biophys Acta Biomembr. 2020 Nov 1;1862(11):183434. [Content Brief]

[5]. Yuya Futagi, et al. Molecular characterization of the orphan transporter SLC16A9, an extracellular pH- and Na+-sensitive creatine transporter. Biochem Biophys Res Commun. 2020 Feb 5;522(2):539-544. [Content Brief]

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