Non Small Cell Lung Cancer (NSCLC)

Definition:

Non Small Cell Lung Cancer (NSCLC) acounts for approximately 85% of all new lung cancer diagnoses. NSCLC are divided into squamous cell carcinomas, adenocarcinomas, and large-cell carcinomas. NSCLC has the occurrence of histological transformation to small cell lung cancer (SCLC), which is accompanied by resistance to the original tyrosine kinase inhibitors (TKIs).

References:

[1]. Rath B, et al. Non-small cell lung cancer-small cell lung cancer transformation as mechanism of resistance to tyrosine kinase inhibitors in lung cancer. Cancer Drug Resist. 2020 Feb 28;3(2):171-178. [Content Brief]

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