NPC intracellular cholesterol transporter 2
Definition:
References:
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[1]. Zhi Xu, et al. Regulation of sterol transport between membranes and NPC2. Biochemistry. 2008 Oct 21;47(42):11134-43. [Content Brief]
[2]. S Naureckiene, et al. Identification of HE1 as the second gene of Niemann-Pick C disease. Science. 2000 Dec 22;290(5500):2298-301. [Content Brief]
[3]. Xin Gong, et al. Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection. Cell. 2016 Jun 2;165(6):1467-1478. [Content Brief]
[4]. Zane Berzina, et al. Niemann-Pick C2 protein regulates sterol transport between plasma membrane and late endosomes in human fibroblasts. Chem Phys Lipids. 2018 Jul;213:48-61. [Content Brief]
[5]. Heng-Ling Liou, et al. NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols. J Biol Chem. 2006 Dec 1;281(48):36710-23. [Content Brief]
[6]. Karim Chikh, et al. Niemann-Pick type C disease: subcellular location and functional characterization of NPC2 proteins with naturally occurring missense mutations. Hum Mutat. 2005 Jul;26(1):20-8. [Content Brief]
[7]. Rodney E Infante, et al. NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15287-92. [Content Brief]
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