Partner and localizer of BRCA2
Definition:
References:
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[1]. Rémi Buisson, et al. PALB2 self-interaction controls homologous recombination. Nucleic Acids Res. 2012 Nov 1;40(20):10312-23. [Content Brief]
[2]. T K Foo, et al. Compromised BRCA1-PALB2 interaction is associated with breast cancer risk. Oncogene. 2017 Jul 20;36(29):4161-4170. [Content Brief]
[3]. Bing Xia, et al. Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. Mol Cell. 2006 Jun 23;22(6):719-729. [Content Brief]
[4]. Eloïse Dray, et al. Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2. Nat Struct Mol Biol. 2010 Oct;17(10):1255-9. [Content Brief]
[5]. Shirley M-H Sy, et al. PALB2 regulates recombinational repair through chromatin association and oligomerization. J Biol Chem. 2009 Jul 3;284(27):18302-10. [Content Brief]
[6]. Rémi Buisson, et al. Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination. Nat Struct Mol Biol. 2010 Oct;17(10):1247-54. [Content Brief]
[7]. Shirley M H Sy, et al. PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7155-60. [Content Brief]
[8]. J-Y Park, et al. Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair. Oncogene. 2014 Oct 2;33(40):4803-12. [Content Brief]
[9]. Rémi Buisson, et al. Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks. Cell Rep. 2014 Feb 13;6(3):553-64. [Content Brief]
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