Phosphatidylinositol-3-phosphatase SAC1
Definition:
References:
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[1]. Bruno Mesmin, et al. A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P exchange by the ER-Golgi tether OSBP. Cell. 2013 Nov 7;155(4):830-43. [Content Brief]
[2]. Eamonn J Dickson, et al. Dynamic formation of ER-PM junctions presents a lipid phosphatase to regulate phosphoinositides. J Cell Biol. 2016 Apr 11;213(1):33-48. [Content Brief]
[3]. Rossella Venditti, et al. The activity of Sac1 across ER-TGN contact sites requires the four-phosphate-adaptor-protein-1. J Cell Biol. 2019 Mar 4;218(3):783-797. [Content Brief]
[4]. James P Zewe, et al. SAC1 degrades its lipid substrate PtdIns4 P in the endoplasmic reticulum to maintain a steep chemical gradient with donor membranes. Elife. 2018 Feb 20;7:e35588. [Content Brief]
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