Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Definition:
References:
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[1]. Kazuo Ueda, et al. Role of HCN4 channel in preventing ventricular arrhythmia. J Hum Genet. 2009 Feb;54(2):115-21. [Content Brief]
[2]. Xinping Xu, et al. Structural basis for the cAMP-dependent gating in the human HCN4 channel. J Biol Chem. 2010 Nov 19;285(47):37082-91. [Content Brief]
[3]. A Ludwig, et al. Two pacemaker channels from human heart with profoundly different activation kinetics. EMBO J. 1999 May 4;18(9):2323-9. [Content Brief]
[4]. Raffaella Milanesi, et al. Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel. N Engl J Med. 2006 Jan 12;354(2):151-7. [Content Brief]
[5]. R Seifert, et al. Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9391-6. [Content Brief]
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