Protein arginine N-methyltransferase 9
Definition:
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA.
References:
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[1]. Yanzhong Yang, et al. PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145. Nat Commun. 2015 Mar 4;6:6428. [Content Brief]
[2]. Andrea Hadjikyriacou, et al. Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2. J Biol Chem. 2015 Jul 3;290(27):16723-43. [Content Brief]
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