Protein transport protein Sec24C

Definition

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B. May more specifically package GPI-anchored proteins through the cargo receptor TMED10. May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5.

References:

[1]. K Tani, et al. Hypothetical protein KIAA0079 is a mammalian homologue of yeast Sec24p. FEBS Lett. 1999 Mar 26;447(2-3):247-50. [Content Brief]

[2]. Carine Bonnon, et al. Selective export of human GPI-anchored proteins from the endoplasmic reticulum. J Cell Sci. 2010 May 15;123(Pt 10):1705-15. [Content Brief]

[3]. Joseph D Mancias, et al. Structural basis of cargo membrane protein discrimination by the human COPII coat machinery. EMBO J. 2008 Nov 5;27(21):2918-28. [Content Brief]

[4]. Joseph D Mancias, et al. The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope. Mol Cell. 2007 May 11;26(3):403-14. [Content Brief]

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