Proton-activated chloride channel
Definition:
Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH. Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling.
References:
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[1]. Florian Ullrich, et al. Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels. Elife. 2019 Jul 18;8:e49187. [Content Brief]
[2]. Junhua Yang, et al. PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel. Science. 2019 Apr 26;364(6438):395-399. [Content Brief]
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