RAS guanyl-releasing protein 1

[1]. J O Ebinu, et al. RasGRP links T-cell receptor signaling to Ras. Blood. 2000 May 15;95(10):3199-203. [Content Brief]

[2]. Suk Hyung Lee, et al. RasGRP1 is required for human NK cell function. J Immunol. 2009 Dec 15;183(12):7931-8. [Content Brief]

[3]. José L Zugaza, et al. Inverted signaling hierarchy between RAS and RAC in T-lymphocytes. Oncogene. 2004 Jul 29;23(34):5823-33. [Content Brief]

[4]. Jeffrey S Iwig, et al. Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1. Elife. 2013 Jul 30;2:e00813. [Content Brief]

[5]. Trever G Bivona, et al. Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1. Nature. 2003 Aug 7;424(6949):694-8. [Content Brief]

[6]. Maria J Caloca, et al. Exchange factors of the RasGRP family mediate Ras activation in the Golgi. J Biol Chem. 2003 Aug 29;278(35):33465-73. [Content Brief]

[7]. Elisabeth Salzer, et al. RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics. Nat Immunol. 2016 Dec;17(12):1352-1360. [Content Brief]

[8]. Huawei Mao, et al. RASGRP1 mutation in autoimmune lymphoproliferative syndrome-like disease. J Allergy Clin Immunol. 2018 Aug;142(2):595-604.e16. [Content Brief]

[9]. María J Caloca, et al. Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1. EMBO J. 2003 Jul 1;22(13):3326-36. [Content Brief]

[10]. Jeroen P Roose, et al. A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Mol Cell Biol. 2005 Jun;25(11):4426-41. [Content Brief]

[11]. Ignacio Perez de Castro, et al. Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus. Mol Cell Biol. 2004 Apr;24(8):3485-96. [Content Brief]