Receptor-type tyrosine-protein phosphatase mu

Definition:

Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation. Promotes CTNND1 dephosphorylation and prevents its cytoplasmic localization where it inhibits SLC2A4 membrane trafficking. In turn, SLC2A4 is directed to the plasma membrane and performs its glucose transporter function.

References:

[1]. Alexandru Radu Aricescu, et al. Molecular analysis of receptor protein tyrosine phosphatase mu-mediated cell adhesion. EMBO J. 2006 Feb 22;25(4):701-12. [Content Brief]

[2]. A Radu Aricescu, et al. Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism. Science. 2007 Aug 31;317(5842):1217-20. [Content Brief]

[3]. G C Zondag, et al. Receptor protein-tyrosine phosphatase RPTPmu binds to and dephosphorylates the catenin p120(ctn). J Biol Chem. 2000 Apr 14;275(15):11264-9. [Content Brief]

[4]. Won Kon Kim, et al. RPTPμ tyrosine phosphatase promotes adipogenic differentiation via modulation of p120 catenin phosphorylation. Mol Biol Cell. 2011 Dec;22(24):4883-91. [Content Brief]

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