1. Biology Dictionary
  2. Ribonucleoside-diphosphate reductase subunit M2 B

Ribonucleoside-diphosphate reductase subunit M2 B

Definition:

Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.

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