Ribosomal protein S6 kinase alpha-6

Definition:

Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.

References:

[1]. Katrien Berns, et al. A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature. 2004 Mar 25;428(6981):431-7. [Content Brief]

[2]. Bettina A Dümmler, et al. Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types. J Biol Chem. 2005 Apr 8;280(14):13304-14. [Content Brief]

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