Ribosome biogenesis protein BOP1

Definition:

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

References:

[1]. Katherine E Sloan, et al. The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress. Cell Rep. 2013 Oct 17;5(1):237-47. [Content Brief]

[2]. Michaela Rohrmoser, et al. Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. Mol Cell Biol. 2007 May;27(10):3682-94. [Content Brief]

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