RNA demethylase ALKBH5
Definition:
References:
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[1]. Guanqun Zheng, et al. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell. 2013 Jan 10;49(1):18-29. [Content Brief]
[2]. Chong Feng, et al. Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition. J Biol Chem. 2014 Apr 25;289(17):11571-11583. [Content Brief]
[3]. Armin Thalhammer, et al. Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α). PLoS One. 2011 Jan 14;6(1):e16210. [Content Brief]
[4]. Chao Xu, et al. Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation. J Biol Chem. 2014 Jun 20;289(25):17299-311. [Content Brief]
[5]. WeiShen Aik, et al. Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation. Nucleic Acids Res. 2014 Apr;42(7):4741-54. [Content Brief]
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