rRNA N6-adenosine-methyltransferase METTL5

Definition:

Catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA. N6-methylation of adenine(1832) in 18S rRNA resides in the decoding center of 18S rRNA and is required for translation and embryonic stem cells (ESCs) pluripotency and differentiation.

References:

[1]. Nhan van Tran, et al. The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112. Nucleic Acids Res. 2019 Sep 5;47(15):7719-7733. [Content Brief]

[2]. Bowen Rong, et al. Ribosome 18S m6A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth. Cell Rep. 2020 Dec 22;33(12):108544. [Content Brief]

[3]. Valentina V Ignatova, et al. The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs. Genes Dev. 2020 May 1;34(9-10):715-729. [Content Brief]

[4]. Caraline Sepich-Poore, et al. The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation. J Biol Chem. 2022 Mar;298(3):101590. [Content Brief]

[5]. Dan Yu, et al. Enzymatic characterization of three human RNA adenosine methyltransferases reveals diverse substrate affinities and reaction optima. J Biol Chem. 2021 Jan-Jun;296:100270. [Content Brief]

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