Serine/threonine-protein kinase Chk2

[1]. Craig Stevens, et al. Chk2 activates E2F-1 in response to DNA damage. Nat Cell Biol. 2003 May;5(5):401-9. [Content Brief]

[2]. S Matsuoka, et al. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science. 1998 Dec 4;282(5395):1893-7. [Content Brief]

[3]. J S Lee, et al. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature. 2000 Mar 9;404(6774):201-4. [Content Brief]

[4]. Zhenkun Lou, et al. MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature. 2003 Feb 27;421(6926):957-61. [Content Brief]

[5]. A Blasina, et al. A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase. Curr Biol. 1999 Jan 14;9(1):1-10. [Content Brief]

[6]. J Falck, et al. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature. 2001 Apr 12;410(6830):842-7. [Content Brief]

[7]. Martina Magni, et al. Chk2 and REGγ-dependent DBC1 regulation in DNA damage induced apoptosis. Nucleic Acids Res. 2014 Dec 1;42(21):13150-60. [Content Brief]

[8]. Elizabeth M Kass, et al. Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456. J Biol Chem. 2007 Oct 12;282(41):30311-21. [Content Brief]

[9]. Lihong Chen, et al. ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. EMBO J. 2005 Oct 5;24(19):3411-22. [Content Brief]

[10]. Shutong Yang, et al. PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2. Nat Cell Biol. 2002 Nov;4(11):865-70. [Content Brief]

[11]. Min-Young Lee, et al. Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation. Cell Cycle. 2008 Sep 1;7(17):2705-9. [Content Brief]

[12]. Ailine Stolz, et al. The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells. Nat Cell Biol. 2010 May;12(5):492-9. [Content Brief]

[13]. Christine M Lovly, et al. Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379. Mol Cell Biol. 2008 Oct;28(19):5874-85. [Content Brief]

[14]. Yasumichi Inoue, et al. Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage. EMBO J. 2007 Apr 18;26(8):2083-93. [Content Brief]

[15]. Igal Louria-Hayon, et al. The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation. J Biol Chem. 2003 Aug 29;278(35):33134-41. [Content Brief]

[16]. Yongjun Tan, et al. Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes. Mol Cell Biol. 2007 Feb;27(3):1007-16. [Content Brief]

[17]. A L Brown, et al. A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3745-50. [Content Brief]

[18]. Dambarudhar Shiba Sankar Hembram, et al. The Viral SUMO-Targeted Ubiquitin Ligase ICP0 is Phosphorylated and Activated by Host Kinase Chk2. J Mol Biol. 2020 Mar 27;432(7):1952-1977. [Content Brief]

[19]. E M Bahassi, et al. The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage. Oncogene. 2008 Jun 26;27(28):3977-85. [Content Brief]

[20]. N Wang, et al. A novel recurrent CHEK2 Y390C mutation identified in high-risk Chinese breast cancer patients impairs its activity and is associated with increased breast cancer risk. Oncogene. 2015 Oct 1;34(40):5198-205. [Content Brief]