2. Biology Dictionary
  3. SET domain-containing lysine methyltransferase 7 (SETD7, also called SET7, SET9, KMT7)

SET domain-containing lysine methyltransferase 7 (SETD7, also called SET7, SET9, KMT7)

Definition:

SET domain-containing lysine methyltransferase 7 (SETD7) belongs to the protein lysine methyltransferase family and can catalyze the monomethylation of histone H3K4, which plays a vital role in the regulation of cell cycle, cell differentiation, DNA damage response and chromatin remodeling through K/R-S/T-K (K is lysine residue) sites and the recognition of substrates mediated by SET, i-SET, and n-SET domains and electrostatic action. SETD7 also can regulate the transcription of several genes including β-catenin, Cullin l and lin-28 homolog A (LIN28A), etc.

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