Sex-determining region Y protein

Definition:

Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).

References:

[1]. S Ferrari, et al. SRY, like HMG1, recognizes sharp angles in DNA. EMBO J. 1992 Dec;11(12):4497-506. [Content Brief]

[2]. Hyun Ju Oh, et al. KRAB: a partner for SRY action on chromatin. Mol Cell Endocrinol. 2006 Mar 9;247(1-2):47-52. [Content Brief]

[3]. Juan Carlos Polanco, et al. Sry and the hesitant beginnings of male development. Dev Biol. 2007 Feb 1;302(1):13-24. [Content Brief]

[4]. Kenji Ohe, et al. A direct role of SRY and SOX proteins in pre-mRNA splicing. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1146-51. [Content Brief]

[5]. M Desclozeaux, et al. Phosphorylation of an N-terminal motif enhances DNA-binding activity of the human SRY protein. J Biol Chem. 1998 Apr 3;273(14):7988-95. [Content Brief]

[6]. E C Murphy, et al. Structural basis for SRY-dependent 46-X,Y sex reversal: modulation of DNA bending by a naturally occurring point mutation. J Mol Biol. 2001 Sep 21;312(3):481-99. [Content Brief]

[7]. K Giese, et al. Distinct DNA-binding properties of the high mobility group domain of murine and human SRY sex-determining factors. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3368-72. [Content Brief]

[8]. Biaoru Li, et al. SRY-directed DNA bending and human sex reversal: reassessment of a clinical mutation uncovers a global coupling between the HMG box and its tail. J Mol Biol. 2006 Jul 7;360(2):310-28. [Content Brief]

[9]. Nelson B Phillips, et al. Sry-directed sex reversal in transgenic mice is robust with respect to enhanced DNA bending: comparison of human and murine HMG boxes. Biochemistry. 2004 Jun 8;43(22):7066-81. [Content Brief]

[10]. C Y King, et al. The SRY high-mobility-group box recognizes DNA by partial intercalation in the minor groove: a topological mechanism of sequence specificity. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11990-4. [Content Brief]

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