SH2 domain-containing adapter protein B

Definition:

Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.

References:

[1]. Cecilia K Lindholm, et al. Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells. Eur J Biochem. 2002 Jul;269(13):3279-88. [Content Brief]

[2]. T Karlsson, et al. Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain protein Shb. Oncogene. 1996 Sep 5;13(5):955-61. [Content Brief]

[3]. M Welsh, et al. Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins. Oncogene. 1998 Feb 19;16(7):891-901. [Content Brief]

[4]. J Dixelius, et al. Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis. Blood. 2000 Jun 1;95(11):3403-11. [Content Brief]

[5]. R Hooshmand-Rad, et al. Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization. Exp Cell Res. 2000 Jun 15;257(2):245-54. [Content Brief]

[6]. Nils Welsh, et al. Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins. Mol Med. 2002 Nov;8(11):695-704. [Content Brief]

[7]. Kristina Holmqvist, et al. The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells. Cell Signal. 2003 Feb;15(2):171-9. [Content Brief]

[8]. T Karlsson, et al. The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells. Cell Growth Differ. 1998 Sep;9(9):757-66. [Content Brief]

[9]. Kristina Holmqvist, et al. The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration. J Biol Chem. 2004 May 21;279(21):22267-75. [Content Brief]

[10]. Charlotte Rolny, et al. Shb promotes blood vessel formation in embryoid bodies by augmenting vascular endothelial growth factor receptor-2 and platelet-derived growth factor receptor-beta signaling. Exp Cell Res. 2005 Aug 15;308(2):381-93. [Content Brief]

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