Signal peptide peptidase-like 2B
Definition:
References:
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[1]. Lucas Martin, et al. Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis. J Biol Chem. 2009 Feb 27;284(9):5662-70. [Content Brief]
[2]. Lucas Martin, et al. Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. J Biol Chem. 2008 Jan 18;283(3):1644-1652. [Content Brief]
[3]. Matthias Voss, et al. Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3). J Biol Chem. 2012 Dec 21;287(52):43401-9. [Content Brief]
[4]. Regina Fluhrer, et al. A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. Nat Cell Biol. 2006 Aug;8(8):894-6. [Content Brief]
[5]. Elena Friedmann, et al. SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production. Nat Cell Biol. 2006 Aug;8(8):843-8. [Content Brief]
[6]. Regina Fluhrer, et al. The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b). J Biol Chem. 2012 Feb 10;287(7):5156-63. [Content Brief]
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