SLIT-ROBO Rho GTPase-activating protein 2B

Definition:

May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2. In contrast to SRGAP2C, it is not able to induce long-lasting changes in synaptic density throughout adulthood.

References:

[1]. Cécile Charrier, et al. Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation. Cell. 2012 May 11;149(4):923-35. [Content Brief]

[2]. Ewoud R E Schmidt, et al. The human-specific paralogs SRGAP2B and SRGAP2C differentially modulate SRGAP2A-dependent synaptic development. Sci Rep. 2019 Dec 10;9(1):18692. [Content Brief]

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