Steroid transmembrane transporter SLC22A24

Definition:

Renal transmembrane organic anion/dicarboxylate exchanger that participates in the reabsorption of conjugated steroids including estradiol-17beta-D-glucuronide (or 17beta-estradiol 17-O-(beta-D-glucuronate)), androstanediol glucuronide (or 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)), and estrone 3-sulfate, as well as bile acids taurocholate and glycocholate, driven by an outward gradient of dicarboxylates such as glutarate or succinate.; [Isoform 2]: Similar uptake function as Isoform 1.; [Isoform 3]: Lack of transporter activity.

References:

[1]. Josefin A Jacobsson, et al. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. Genomics. 2007 Nov;90(5):595-609. [Content Brief]

[2]. Sook Wah Yee, et al. Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies. PLoS Genet. 2019 Sep 25;15(9):e1008208. [Content Brief]

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