Toll-like receptor 8
Definition:
References:
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[1]. Wilhelm Greulich, et al. TLR8 Is a Sensor of RNase T2 Degradation Products. Cell. 2019 Nov 27;179(6):1264-1275.e13. [Content Brief]
[2]. Leonhard X Heinz, et al. TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9. Nature. 2020 May;581(7808):316-322. [Content Brief]
[3]. Shuting Zhang, et al. Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat Chem Biol. 2018 Jan;14(1):58-64. [Content Brief]
[4]. Hiromi Tanji, et al. Toll-like receptor 8 senses degradation products of single-stranded RNA. Nat Struct Mol Biol. 2015 Feb;22(2):109-15. [Content Brief]
[5]. Sarah L Doyle, et al. Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. J Biol Chem. 2007 Dec 21;282(51):36953-60. [Content Brief]
[6]. Hiromi Tanji, et al. Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands. Science. 2013 Mar 22;339(6126):1426-9. [Content Brief]
[7]. Jinzhong Qin, et al. TLR8-mediated NF-kappaB and JNK activation are TAK1-independent and MEKK3-dependent. J Biol Chem. 2006 Jul 28;281(30):21013-21021. [Content Brief]
[8]. Noriko Ishii, et al. Endosomal localization of TLR8 confers distinctive proteolytic processing on human myeloid cells. J Immunol. 2014 Nov 15;193(10):5118-28. [Content Brief]
[9]. Hiromi Tanji, et al. Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3012-7. [Content Brief]
[10]. Grant R Campbell, et al. SARS-CoV-2, SARS-CoV-1, and HIV-1 derived ssRNA sequences activate the NLRP3 inflammasome in human macrophages through a non-classical pathway. iScience. 2021 Apr 23;24(4):102295. [Content Brief]
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