U4/U6.U5 tri-snRNP-associated protein 2

Definition:

Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin-specific peptidase activity.

References:

[1]. Dmitry E Agafonov, et al. Molecular architecture of the human U4/U6.U5 tri-snRNP. Science. 2016 Mar 25;351(6280):1416-20. [Content Brief]

[2]. Renske J van Leuken, et al. Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B. Cell Cycle. 2008 Sep 1;7(17):2710-9. [Content Brief]

[3]. O V Makarova, et al. The 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomes. EMBO J. 2001 May 15;20(10):2553-63. [Content Brief]

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