Ubiquitin-associated domain-containing protein 1

Definition:

Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.

References:

[1]. Takumi Kamura, et al. Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. Nat Cell Biol. 2004 Dec;6(12):1229-35. [Content Brief]

[2]. Shuhei Kotoshiba, et al. Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase. J Biol Chem. 2005 May 6;280(18):17694-700. [Content Brief]

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