Unconventional myosin-Ie

Definition

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14.

References:

[1]. Elizabeth A Feeser, et al. Myo1e binds anionic phospholipids with high affinity. Biochemistry. 2010 Nov 2;49(43):9353-60. [Content Brief]

[2]. Mohammed El Mezgueldi, et al. The kinetic mechanism of Myo1e (human myosin-IC). J Biol Chem. 2002 Jun 14;277(24):21514-21. [Content Brief]

[3]. Mira Krendel, et al. Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis. FEBS Lett. 2007 Feb 20;581(4):644-50. [Content Brief]

生物医学辞典

生物医学辞典は、生物学の学術用語と専門データの包括的で専門的なデータベースです。すべての説明は、権威ある書籍や高いＩＦの文献に基づいており、知りたい生物医学用語の正確な説明を得ることができます。

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