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Unconventional myosin-XVIIIa

Definition:

May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking. Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages. Strongly enhances natural killer cell cytotoxicity.

References:

[1]. Zvjezdana Sever-Chroneos, et al. Surfactant protein A (SP-A)-mediated clearance of Staphylococcus aureus involves binding of SP-A to the staphylococcal adhesin eap and the macrophage receptors SP-A receptor 210 and scavenger receptor class A. J Biol Chem. 2011 Feb 11;286(6):4854-70. [Content Brief]

[2]. Michelle M Ng, et al. GOLPH3L antagonizes GOLPH3 to determine Golgi morphology. Mol Biol Cell. 2013 Mar;24(6):796-808. [Content Brief]

[3]. Ivan Tan, et al. A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow. Cell. 2008 Oct 3;135(1):123-36. [Content Brief]

[4]. Linlin Yang, et al. SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation. PLoS One. 2015 May 12;10(5):e0126576. [Content Brief]

[5]. Ching-Hui Yang, et al. Identification of the surfactant protein A receptor 210 as the unconventional myosin 18A. J Biol Chem. 2005 Oct 14;280(41):34447-57. [Content Brief]

[6]. Holly C Dippold, et al. GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote budding. Cell. 2009 Oct 16;139(2):337-51. [Content Brief]

[7]. A De Masson, et al. Identification of CD245 as myosin 18A, a receptor for surfactant A: A novel pathway for activating human NK lymphocytes. Oncoimmunology. 2016 Jan 13;5(5):e1127493. [Content Brief]

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