Zinc finger protein 143

Definition:

Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8.

References:

[1]. Chih-Chi Yuan, et al. CHD8 associates with human Staf and contributes to efficient U6 RNA polymerase III transcription. Mol Cell Biol. 2007 Dec;27(24):8729-38. [Content Brief]

[2]. J C Rincon, et al. Molecular cloning of a cDNA encoding human SPH-binding factor, a conserved protein that binds to the enhancer-like region of the U6 small nuclear RNA gene promoter. Nucleic Acids Res. 1998 Nov 1;26(21):4846-52. [Content Brief]

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