Zinc finger protein 16

Definition:

Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Also plays a role as an inhibitor of cell apoptosis.

References:

[1]. Xiao-Bo Li, et al. Zinc finger protein HZF1 promotes K562 cell proliferation by interacting with and inhibiting INCA1. Mol Med Rep. 2011 Nov-Dec;4(6):1131-7. [Content Brief]

[2]. Min-Jie Deng, et al. Identification of the trans-activation domain and the nuclear location signals of human zinc finger protein HZF1 (ZNF16). Mol Biotechnol. 2010 Feb;44(2):83-9. [Content Brief]

[3]. H Peng, et al. Identification and characterization of a novel zinc finger protein (HZF1) gene and its function in erythroid and megakaryocytic differentiation of K562 cells. Leukemia. 2006 Jun;20(6):1109-16. [Content Brief]

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