Zinc finger protein 580

Definition:

Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation.

References:

[1]. Ren DangLi, et al. ROS-induced ZNF580 expression: a key role for H2O2/NF-κB signaling pathway in vascular endothelial inflammation. Mol Cell Biochem. 2012 Jan;359(1-2):183-91. [Content Brief]

[2]. Hui-Yan Sun, et al. Sphingosine-1-phosphate induces human endothelial VEGF and MMP-2 production via transcription factor ZNF580: novel insights into angiogenesis. Biochem Biophys Res Commun. 2010 May 7;395(3):361-6. [Content Brief]

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