Zinc finger protein 593

Definition:

Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome. Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity.

References:

[1]. Xiaomeng Liang, et al. Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat Commun. 2020 Jul 15;11(1):3542. [Content Brief]

[2]. A Terunuma, et al. A novel genetic system to isolate a dominant negative effector on DNA-binding activity of Oct-2. Nucleic Acids Res. 1997 May 15;25(10):1984-90. [Content Brief]

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