Zinc finger protein 703

Definition:

Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.

References:

[1]. Fabrice Sircoulomb, et al. ZNF703 gene amplification at 8p12 specifies luminal B breast cancer. EMBO Mol Med. 2011 Mar;3(3):153-66. [Content Brief]

[2]. Daniel G Holland, et al. ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium. EMBO Mol Med. 2011 Mar;3(3):167-80. [Content Brief]

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