Zinc finger protein SNAI2

Definition:

Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.

References:

[1]. Karen M Hajra, et al. The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res. 2002 Mar 15;62(6):1613-8. [Content Brief]

[2]. Elisabetta Lambertini, et al. Slug gene expression supports human osteoblast maturation. Cell Mol Life Sci. 2009 Nov;66(22):3641-53. [Content Brief]

[3]. K Hemavathy, et al. Human Slug is a repressor that localizes to sites of active transcription. Mol Cell Biol. 2000 Jul;20(14):5087-95. [Content Brief]

[4]. Roberta Piva, et al. Slug contributes to the regulation of CXCL12 expression in human osteoblasts. Exp Cell Res. 2011 May 1;317(8):1159-68. [Content Brief]

[5]. Manish K Tripathi, et al. Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells. J Biol Chem. 2005 Apr 29;280(17):17163-71. [Content Brief]

[6]. Frances E Turner, et al. Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes. J Biol Chem. 2006 Jul 28;281(30):21321-21331. [Content Brief]

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