Zinc finger transcription factor Trps1

Definition:

Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.

References:

[1]. Frank J Kaiser, et al. SUMOylation modulates transcriptional repression by TRPS1. Biol Chem. 2007 Apr;388(4):381-90. [Content Brief]

[2]. Frank J Kaiser, et al. The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor. J Biol Chem. 2003 Oct 3;278(40):38780-5. [Content Brief]

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