ROR2 - receptor tyrosine kinase like orphan receptor 2 Gene

Also Known as BDB; BDB1; NTRKR2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4920

About ROR2

Cytogenetic location: 9q22.31 Genomic coordinates (GRCh38): 9:91,722,601-91,950,228 (from NCBI)

This gene has 8 transcripts (splice variants), 195 orthologues, 53 paralogues and is associated with 6 phenotypes. Broad expression in endometrium (RPKM 5.4), gall bladder (RPKM 3.7) and 18 other tissues.

Summary

The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008]

ROR2 Products (2)

mRNA Protein Name
NM_001318204.2 NP_001305133.1 tyrosine-protein kinase transmembrane receptor ROR2 isoform 2 precursor
NM_004560.4 NP_004551.2 tyrosine-protein kinase transmembrane receptor ROR2 isoform 1 precursor
Molecular Function GO Annotation Evidence References Source
enables Wnt-protein binding IPI
IPI: Inferred from physical interaction
19486338 GOA
enables mitogen-activated protein kinase kinase kinase binding IPI
IPI: Inferred from physical interaction
18762249 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22939624 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
19486338 GOA
involved in signal transduction IMP
IMP: Inferred from mutant phenotype
19486338 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ROR2 Protein Structure

I-set

I-set: Immunoglobulin I-set domain (64 - 150)

Fz

Fz: Fz domain (174 - 301)

Kringle

Kringle: Kringle domain (316 - 394)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (474 - 746)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 943 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase transmembrane receptor ROR2

  • neurotrophic tyrosine kinase receptor-related 2

ROR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ROR2 Q01974 ALG13 Homo sapiens Q9NP73-4 32296183
Intra
ROR2 Q01974 ALG13 Homo sapiens Q9NP73-4 32296183
Intra
ROR2 Q01974 ALG13 Homo sapiens Q9NP73-4 32296183
Intra
ROR2 Q01974 KRTAP19-7 Homo sapiens Q3SYF9 32296183
Intra
ROR2 Q01974 KRTAP19-7 Homo sapiens Q3SYF9 32296183
Intra
ROR2 Q01974 KRTAP19-7 Homo sapiens Q3SYF9 32296183
Intra
ROR2 Q01974 LHX6 Homo sapiens Q9UPM6 32296183
Intra
ROR2 Q01974 LHX6 Homo sapiens Q9UPM6 32296183
Intra
ROR2 Q01974 LHX6 Homo sapiens Q9UPM6 32296183
Intra
ROR2 Q01974 KRTAP6-2 Homo sapiens Q3LI66 32296183
Intra
ROR2 Q01974 KRTAP6-2 Homo sapiens Q3LI66 32296183
Intra
ROR2 Q01974 KRTAP6-2 Homo sapiens Q3LI66 32296183
Intra
ROR2 Q01974 ACTMAP Homo sapiens Q5BKX5-3 32296183
Intra
ROR2 Q01974 ACTMAP Homo sapiens Q5BKX5-3 32296183
Intra
ROR2 Q01974 ACTMAP Homo sapiens Q5BKX5-3 32296183
Intra
ROR2 Q01974 FAM168B Homo sapiens A1KXE4-2 32296183
Intra
ROR2 Q01974 FAM168B Homo sapiens A1KXE4-2 32296183
Intra
ROR2 Q01974 PRR20D Homo sapiens P86480 32296183
Intra
ROR2 Q01974 PRR20D Homo sapiens P86480 32296183
Intra
ROR2 Q01974 C10orf55 Homo sapiens Q5SWW7 32296183
Intra
ROR2 Q01974 C10orf55 Homo sapiens Q5SWW7 32296183
Intra
ROR2 Q01974 C10orf55 Homo sapiens Q5SWW7 32296183
Intra
ROR2 Q01974 CREM Homo sapiens Q03060-25 32296183
Intra
ROR2 Q01974 CREM Homo sapiens Q03060-25 32296183
Intra
ROR2 Q01974 CREM Homo sapiens Q03060-25 32296183
Intra
ROR2 Q01974 KIAA1218 Homo sapiens A4D0Q3 32296183
Intra
ROR2 Q01974 KIAA1218 Homo sapiens A4D0Q3 32296183
Intra
ROR2 Q01974 PRR23E Homo sapiens Q8N813 32296183
Intra
ROR2 Q01974 KRTAP7-1 Homo sapiens Q8IUC3 32296183
Intra
ROR2 Q01974 KRTAP7-1 Homo sapiens Q8IUC3 32296183
Intra
ROR2 Q01974 KRTAP7-1 Homo sapiens Q8IUC3 32296183
Intra
ROR2 Q01974 FOSB Homo sapiens P53539 32296183
Intra
ROR2 Q01974 FOSB Homo sapiens P53539 32296183
Intra
ROR2 Q01974 HSP90AB1 Homo sapiens P08238 22939624
Intra
ROR2 Q01974 STOX1 Homo sapiens Q6ZVD7 32296183
Intra
ROR2 Q01974 STOX1 Homo sapiens Q6ZVD7 32296183
Intra
ROR2 Q01974 STOX1 Homo sapiens Q6ZVD7 32296183
Intra
ROR2 Q01974 ISX Homo sapiens Q2M1V0 32296183
Intra
ROR2 Q01974 MSX2 Homo sapiens P35548 32296183
Intra
ROR2 Q01974 MSX2 Homo sapiens P35548 32296183
Intra
ROR2 Q01974 BHLHE40 Homo sapiens O14503 32296183
Intra
ROR2 Q01974 BHLHE40 Homo sapiens O14503 32296183
Intra
ROR2 Q01974 DAZAP2 Homo sapiens Q15038 32296183
Intra
ROR2 Q01974 DAZAP2 Homo sapiens Q15038 32296183
Intra
ROR2 Q01974 DAZAP2 Homo sapiens Q15038 32296183
Intra
ROR2 Q01974 PLA2G10 Homo sapiens O15496 32296183
Intra
ROR2 Q01974 PLA2G10 Homo sapiens O15496 32296183
Intra
ROR2 Q01974 CRX Homo sapiens O43186 32296183
Intra
ROR2 Q01974 CRX Homo sapiens O43186 32296183
Intra
ROR2 Q01974 CRX Homo sapiens O43186 31515488
Intra
ROR2 Q01974 SOX14 Homo sapiens O95416 32296183
Intra
ROR2 Q01974 SOX14 Homo sapiens O95416 32296183
Intra
ROR2 Q01974 POU2AF1 Homo sapiens Q16633 32296183
Intra
ROR2 Q01974 POU2AF1 Homo sapiens Q16633 32296183
Intra
ROR2 Q01974 POU2AF1 Homo sapiens Q16633 32296183
Intra
ROR2 Q01974 C1orf94 Homo sapiens Q6P1W5 32296183
Intra
ROR2 Q01974 C1orf94 Homo sapiens Q6P1W5 32296183
Intra
ROR2 Q01974 C1orf94 Homo sapiens Q6P1W5 32296183
Intra
ROR2 Q01974 ARID5A Homo sapiens Q03989 32296183
Intra
ROR2 Q01974 ARID5A Homo sapiens Q03989 32296183
Intra
ROR2 Q01974 ARID5A Homo sapiens Q03989 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ROR2 Proteins

Cat. No. Product Name Accession Purity
HY-P71263 ROR2 Protein, Human (HEK293, His) Q01974 (E34-G403) ≥ 95%, as determined by reducing SDS-PAGE.

ROR2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81390 ROR2 Antibody (YA1135) IHC-P Human
HY-P81390A ROR2 Antibody (YA1135)(PBS only) IHC-P Human
HY-P84466 ROR2 Antibody (YA4163) FC, ELISA Human
HY-P84466A ROR2 Antibody (YA4163)(PBS only) FC, ELISA Human

Related Diseases

Diseases Alias
Robinow Syndrome, Autosomal Recessive 1
  • Robinow Syndrome, Autosomal Recessive

  • Autosomal Recessive Robinow Syndrome

  • Covesdem Syndrome

  • RRS1

  • Costovertebral Segmentation Defect-Mesomelia Syndrome

  • Rrs

  • Costovertebral Segmentation Defect With Mesomelia, Formerly

  • Covesdem Syndrome, Formerly

  • Costovertebral Segmentation Defect With Mesomelia

  • Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals

  • Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly

  • Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals

  • Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly

  • Robinow, Autosomal Recessive Syndrome, Type 1

Brachydactyly, Type B1
  • Brachydactyly Type B1

  • Brachydactyly Type B

  • BDB1

  • Brachydactyly, Type B

  • Bdb

  • Brachydactyly B1

Robinow Syndrome
  • Acral Dysostosis With Facial And Genital Abnormalities

  • Fetal Face Syndrome

  • Robinow Dwarfism

  • Mesomelic Dwarfism-Small Genitalia Syndrome

  • Robinow-Silverman-Smith Syndrome

  • Costovertebral Segmentation Defect With Mesomelia

  • Covesdem Syndrome

  • Robinow'S Syndrome

  • Robinow-Silverman Syndrome

Brachydactyly
Proximal Symphalangism
  • Cushing'S Symphalangism

  • Symphalangism, Proximal

  • Hereditary Absence Of Proximal Interphalangeal Joints

  • Strasburger-Hawkins-Eldridge Syndrome

  • Strasburger-Hawkins-Eldridge-Hargrave-Mckusick Syndrome

  • Symphalangism, Proximal, 1a

  • Symphalangism, Proximal, 1b

  • Vessel'S Syndrome

  • Symphalangism, Cushing Type

Basal Cell Nevus Syndrome
  • Nevoid Basal Cell Carcinoma Syndrome

  • Gorlin Syndrome

  • Nbccs

  • BCNS

  • Gorlin-Goltz Syndrome

  • Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies

  • Cerebral Gigantism Jaw Cysts

  • Cramer Niederdellmann Syndrome

  • Gorlin Syndrome Or Gorlin-Goltz Syndrome

  • Naevoid Basal Cell Carcinoma Syndrome

Fetal Akinesia Deformation Sequence 1
  • Fetal Akinesia Deformation Sequence

  • Fads

  • Fetal Akinesia Sequence

  • FADS1

  • Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia

  • Pena-Shokeir Syndrome Type 1

  • Fetal Akinesia Deformation Sequence Syndrome

  • Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome

  • Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia

  • Pena-Shokeir Syndrome, Type I

  • Foetal Akinesia Deformation Sequence Syndrome

  • Foetal Akinesia Sequence

  • Fetal Akinesia Deformation Sequence Syndrome 1

  • Pena-Shokeir Syndrome, Type 1

  • Pena Shokeir Syndrome, Type 1

  • Akinesia, Fetal, Deformation Sequence

  • Akinesia, Fetal, Deformation Sequence, Type 1

  • Pena-Shokeir Syndrome Type I

Distal Arthrogryposis
  • Arthrogryposis Multiplex Congenita

  • Arthrogryposis

  • Congenital Multiple Arthrogryposis

  • Congenital Arthromyodysplasia

  • Fibrous Ankylosis Of Multiple Joints

  • Guerin-Stern Syndrome

  • Guérin-Stern Syndrome

  • Myodystrophia Fetalis Deformans

  • Otto Syndrome

  • Rocher-Sheldon Syndrome

  • Rossi Syndrome

  • Amc

  • Multiple Congenital Arthrogryposis

  • Arthrogryposis Syndrome

  • Arthrogryposis, Distal

  • Distal Arthrogryposis Syndrome

  • Freeman-Sheldon Syndrome

  • Arthrogryposis, Distal, Type 2b

  • Congenital Multiplex Arthrogryposis

  • Amyoplasia Congenita

  • Congenital Amyoplasia

  • Amc - [Arthrogryposis Multiplex Congenita]

Autosomal Dominant Robinow Syndrome
  • Fetal Face Syndrome

  • Robinow Syndrome, Autosomal Dominant

Brachydactyly, Type C
  • Brachydactyly Type C

  • BDC

  • Brachydactyly Haws Type

  • Brachydactyly, Haws Type

  • Brachydactyly C

Fallopian Tube Serous Adenocarcinoma
Brachydactyly, Type B2
  • Brachydactyly Type B2

  • BDB2

  • Brachydactyly B2

Breast Cancer
  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation

Hepatocellular Carcinoma
  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris ROR2 VGNC VGNC:45694
Felis catus ROR2 VGNC VGNC:64720
Mus musculus ROR2 MGD MGI:1347521
Bos taurus ROR2 VGNC VGNC:34087
Rattus norvegicus ROR2 RGD RGD:1305275
Macaca mulatta ROR2 VGNC VGNC:76716
Others ROR2 NCBI