ROR2 - receptor tyrosine kinase like orphan receptor 2 Gene
Also Known as BDB; BDB1; NTRKR2
Species: Homo sapiens
About ROR2
This gene has 8 transcripts (splice variants), 195 orthologues, 53 paralogues and is associated with 6 phenotypes. Broad expression in endometrium (RPKM 5.4), gall bladder (RPKM 3.7) and 18 other tissues.
Summary
The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008]
ROR2 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001318204.2 | NP_001305133.1 | tyrosine-protein kinase transmembrane receptor ROR2 isoform 2 precursor |
| NM_004560.4 | NP_004551.2 | tyrosine-protein kinase transmembrane receptor ROR2 isoform 1 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables Wnt-protein binding |
IPI
IPI: Inferred from physical interaction
|
19486338 | GOA |
| enables mitogen-activated protein kinase kinase kinase binding |
IPI
IPI: Inferred from physical interaction
|
18762249 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
22939624 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in positive regulation of cell migration |
IDA
IDA: Inferred from direct assay
|
19486338 | GOA |
| involved in signal transduction |
IMP
IMP: Inferred from mutant phenotype
|
19486338 | GOA |
ROR2 Protein Structure
I-set: Immunoglobulin I-set domain (64 - 150)
Fz: Fz domain (174 - 301)
Kringle: Kringle domain (316 - 394)
Pkinase_Tyr: Protein tyrosine kinase (474 - 746)
- 0
- 200
- 400
- 600
- 800
- 943 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
tyrosine-protein kinase transmembrane receptor ROR2 |
|
ROR2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
ROR2 | Q01974 | ALG13 | Homo sapiens | Q9NP73-4 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | ALG13 | Homo sapiens | Q9NP73-4 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | ALG13 | Homo sapiens | Q9NP73-4 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | KRTAP19-7 | Homo sapiens | Q3SYF9 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | KRTAP19-7 | Homo sapiens | Q3SYF9 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | KRTAP19-7 | Homo sapiens | Q3SYF9 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | LHX6 | Homo sapiens | Q9UPM6 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | LHX6 | Homo sapiens | Q9UPM6 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | LHX6 | Homo sapiens | Q9UPM6 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | KRTAP6-2 | Homo sapiens | Q3LI66 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | KRTAP6-2 | Homo sapiens | Q3LI66 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | KRTAP6-2 | Homo sapiens | Q3LI66 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | ACTMAP | Homo sapiens | Q5BKX5-3 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | ACTMAP | Homo sapiens | Q5BKX5-3 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | ACTMAP | Homo sapiens | Q5BKX5-3 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | FAM168B | Homo sapiens | A1KXE4-2 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | FAM168B | Homo sapiens | A1KXE4-2 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | PRR20D | Homo sapiens | P86480 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | PRR20D | Homo sapiens | P86480 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | C10orf55 | Homo sapiens | Q5SWW7 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | C10orf55 | Homo sapiens | Q5SWW7 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | C10orf55 | Homo sapiens | Q5SWW7 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | CREM | Homo sapiens | Q03060-25 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | CREM | Homo sapiens | Q03060-25 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | CREM | Homo sapiens | Q03060-25 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | KIAA1218 | Homo sapiens | A4D0Q3 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | KIAA1218 | Homo sapiens | A4D0Q3 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | PRR23E | Homo sapiens | Q8N813 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | KRTAP7-1 | Homo sapiens | Q8IUC3 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | KRTAP7-1 | Homo sapiens | Q8IUC3 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | KRTAP7-1 | Homo sapiens | Q8IUC3 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | FOSB | Homo sapiens | P53539 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | FOSB | Homo sapiens | P53539 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | HSP90AB1 | Homo sapiens | P08238 | 22939624 | |
|
Intra
|
ROR2 | Q01974 | STOX1 | Homo sapiens | Q6ZVD7 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | STOX1 | Homo sapiens | Q6ZVD7 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | STOX1 | Homo sapiens | Q6ZVD7 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | ISX | Homo sapiens | Q2M1V0 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | MSX2 | Homo sapiens | P35548 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | MSX2 | Homo sapiens | P35548 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | BHLHE40 | Homo sapiens | O14503 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | BHLHE40 | Homo sapiens | O14503 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | DAZAP2 | Homo sapiens | Q15038 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | DAZAP2 | Homo sapiens | Q15038 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | DAZAP2 | Homo sapiens | Q15038 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | PLA2G10 | Homo sapiens | O15496 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | PLA2G10 | Homo sapiens | O15496 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | CRX | Homo sapiens | O43186 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | CRX | Homo sapiens | O43186 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | CRX | Homo sapiens | O43186 | 31515488 | |
|
Intra
|
ROR2 | Q01974 | SOX14 | Homo sapiens | O95416 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | SOX14 | Homo sapiens | O95416 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | POU2AF1 | Homo sapiens | Q16633 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | POU2AF1 | Homo sapiens | Q16633 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | POU2AF1 | Homo sapiens | Q16633 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | C1orf94 | Homo sapiens | Q6P1W5 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | C1orf94 | Homo sapiens | Q6P1W5 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | C1orf94 | Homo sapiens | Q6P1W5 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | ARID5A | Homo sapiens | Q03989 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | ARID5A | Homo sapiens | Q03989 | 32296183 | |
|
Intra
|
ROR2 | Q01974 | ARID5A | Homo sapiens | Q03989 | 32296183 |
Recombinant ROR2 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P71263 | ROR2 Protein, Human (HEK293, His) | Q01974 (E34-G403) | ≥ 95%, as determined by reducing SDS-PAGE. |
ROR2 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81390 | ROR2 Antibody (YA1135) | IHC-P | Human |
| HY-P81390A | ROR2 Antibody (YA1135)(PBS only) | IHC-P | Human |
| HY-P84466 | ROR2 Antibody (YA4163) | FC, ELISA | Human |
| HY-P84466A | ROR2 Antibody (YA4163)(PBS only) | FC, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Robinow Syndrome, Autosomal Recessive 1 |
|
|
| Brachydactyly, Type B1 |
|
|
| Robinow Syndrome |
|
|
| Brachydactyly |
|
|
| Proximal Symphalangism |
|
|
| Basal Cell Nevus Syndrome |
|
|
| Fetal Akinesia Deformation Sequence 1 |
|
|
| Distal Arthrogryposis |
|
|
| Autosomal Dominant Robinow Syndrome |
|
|
| Brachydactyly, Type C |
|
|
| Fallopian Tube Serous Adenocarcinoma |
|
|
| Brachydactyly, Type B2 |
|
|
| Breast Cancer |
|
|
| Hepatocellular Carcinoma |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | ROR2 | VGNC | VGNC:45694 |
| Felis catus | ROR2 | VGNC | VGNC:64720 |
| Mus musculus | ROR2 | MGD | MGI:1347521 |
| Bos taurus | ROR2 | VGNC | VGNC:34087 |
| Rattus norvegicus | ROR2 | RGD | RGD:1305275 |
| Macaca mulatta | ROR2 | VGNC | VGNC:76716 |
| Others | ROR2 | NCBI |