U 92163
U 92163 is an HIV-2 protease inhibitor. It is a synthetic peptidomimetic transition-state analog. U 92163 binds in an extended conformation along the length of the enzyme's binding cleft, and forms hydrogen bonds with the catalytic aspartate pair and other protease residues to block enzyme activity. U 92163 can be used in research on acquired immunodeficiency syndrome (AIDS).
For research use only. We do not sell to patients.
- CAS No.: 149607-21-6
- Formula: C34H51N5O5
- Molecular Weight:609.81
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
U 92163 plays a role in the crystalline HIV-2 protease/inhibitor complex by occupying the substrate-binding pocket of the protease binding cleft, forming a hydrogen bond network with the catalytic site Asp25/Asp125 and side chain residues, and inducing protein conformational changes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 149607-21-6
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Molecular Weight 609.81
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Formula C34H51N5O5
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SMILES
C(N[C@H](C(N[C@@H](CC1CCCCC1)[C@H](C[C@H](C(NCC(C)(C)C)=O)[C@H](C)C)O)=O)CC(N)=O)(=O)C2=NC3=C(C=C2)C=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
U 92163 Related Classifications
HY-187623 Related Classifications
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