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Cat. No.: HY-181805

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HDAC6-IN-76

HDAC6-IN-76 (Compound G25) is a selective HDAC6 inhibitor with an IC₅₀ of 12 nM. HDAC6-IN-76 induces Autophagy in a p53-dependent manner. HDAC6-IN-76 induces Apoptosis in a p53-dependent manner. HDAC6-IN-76 exhibits anticancer activity against hematologic malignancies, including acute myeloid leukemia.

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CAS No.: 3110559-06-0
Formule: C₂₄H₃₂N₂O₇
Masse moléculaire:460.52

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HDAC6-IN-76 Chemical Structure

CAS No.: 3110559-06-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

HDAC6

12 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform HDAC :

In Vitro

HDAC6-IN-76 is a potent and selective HDAC6 inhibitor with an IC₅₀ of 12 nM^[1].
HDAC6-IN-76 exhibits broad-spectrum and potent antiproliferative activity against both leukemia and solid tumor cell lines, with particularly prominent activity against MV4-11 cells, with an IC₅₀ of 0.028 μM^[1].
HDAC6-IN-76 (0.1-1 μM; 24 h) effectively inhibits the migration of HCT116 colon cancer cells in a dose-dependent manner^[1].
HDAC6-IN-76 (0.1-1 μM; 24 h) induces autophagy in a concentration-dependent manner in MV4-11 and HL60 leukemia cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MV4-11 and HL60 leukemia cells
Concentration:

0.1-1 μM
Incubation Time:

24 h
Result:

Led to a concentration-dependent increase in LC3B-II expression (conversion of LC3B-I to LC3B-II) in both MV4-11 and HL60 cells.
Caused a concentration-dependent decrease in p62 expression in both MV4-11 and HL60 cells, indicating enhanced autophagic flux.

Cell Cycle Analysis^[1]

Cell Line:

MV4-11 (p53-wild type) and HL60 (p53-null) leukemia cells
Concentration:

1 μM
Incubation Time:

24 h
Result:

Arrested MV4-11 cells in the G0/G1 phase, with 86.71% of cells in this phase.
Arrested HL60 cells in the G2/M phase, with 34.13% of cells in this phase.

Parmacokinetics

Species	Dose	Route	T_1/2	T_max	C_max	AUC_0-t	AUC_0-∞	MRT_0-t	MRT_0-∞	Bioavailability	C₀
Rat^[1]	2 mg/kg	i.v.	0.208 h	0.0833 h	123 ng/mL	39.3 ng·h/mL	40.8 ng·h/mL	0.178 h	0.220 h	/	213 ng/mL
Rat^[1]	10 mg/kg	i.p.	0.305 h	0.25 h	221 ng/mL	135 ng·h/mL	137 ng·h/mL	0.540 h	0.566 h	67.3 %	/

In Vivo

HDAC6-IN-76 (20 mg/kg; i.p.; once daily) shows antileukemic activity in a
MOLM-13-Luc acute myeloid leukemia xenograft mouse model, as evidenced by suppressed tumor progression and a trend toward prolonged survival^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3110559-06-0
Masse moléculaire 460.52
Formule C₂₄H₃₂N₂O₇
SMILES

C[C@@]12O[C@]3(O[C@@H]([C@@H]([C@]([H])(CC[C@H]([C@@H]4CC2)C)[C@@]34OO1)C)OCC5=CC=CC(/C=C/C(NO)=O)=N5)[H]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Liu W, et al. Discovery of Potent HDAC6-Selective Inhibitors Based on Artemisinin: Design, Synthesis, and Antitumor Evaluation. J Med Chem. 2026;69(4):5024-5054. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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HDAC6-IN-76

Voir tous les produits spécifiques à Isoform HDAC

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

HDAC6-IN-76 Related Classifications

HY-181805 Related Classifications